Interpolymer interactions between the countercharged polymers like Eudragit® EPO (polycation) and hypromellose acetate succinate. PDF | The objective of this investigation was to evaluate the potential of Eudragit EPO nanoparticles (EPO NP) in improving therapeutic efficacy. Download scientific diagram | Molecular structures of (a) MFA, (b) EUDRAGIT® EPO, and (c) EUDRAGIT® L from publication: Stabilization of a.
|Genre:||Health and Food|
|Published (Last):||20 March 2016|
|PDF File Size:||2.97 Mb|
|ePub File Size:||9.15 Mb|
|Price:||Free* [*Free Regsitration Required]|
The manufactured tablets showed low weight variation indicating that the wet granulation method is an acceptable method for preparing good-quality matrix tablets. Thus, it can be concluded that the use of single anionic or cationic polymer will not provide sustained drug release from the matrix tablets.
The drug release from the matrix tablets containing a single polymer as matrix former in 0. The authors are grateful to Mylan laboratories Limited, Hyderabad, India, for the generous gift samples of acetaminophen and excipients.
Eur J Pharm Biopharm. Or if you don’t have an account with us yet, then click here to register. The selection of anionic and cationic polymers forming the Eudagit can be made on the basis of their physicochemical properties such as biocompatibility, physicochemical stability, pH-dependent solubility, and swellability characteristics, etc. The product, PEC complex, was isolated and then dried, before being utilized as a eudraigt carrier epk modified drug release Development of extended-release solid dispersions of nonsteroidal antiinflammatory drugs with aqueous polymeric dispersions: The model with the highest correlation coefficient was considered to be the best-fitting one.
Received Aug 4; Accepted Nov Effect of formulation variables on dissolution of water-soluble drug from polyelectrolyte complex beads. The tablets were weighed initially and rotated at 25 rpm for 4 min, and the samples were then reweighed. Dried granules were mixed with the different proportion of polymers in a polybag for 10 min and further lubricated with magnesium stearate previously passed through 60 mesh sieve.
The data was analyzed by the regression coefficient method. Aliquots of 10 mL were withdrawn from the dissolution apparatus at different time intervals and filtered through a cellulose acetate membrane 0. Polymethacrylate polymers have been widely used in pharmaceutical formulations as film-coating agent and as matrix carriers in solid dispersion preparation and in hot-melt extrusion processes 13 — Tablets with mg of the polymers were compacted manually from the physical mixtures using a 9-mm punch in a tablet compression machine.
The mean of three determinations was used to calculate the drug release from each of the formulation. The physical mixture of polymer mixtures showed the bands for the single components data not shown.
This is due to the high degree of interaction that could exist as both polymers were ionized and maximum level charge density was obtained especially in acidic and buffer media. To describe the kinetics eudrwgit drug release from the selected matrix formulation F8release data was analyzed according to different kinetic equations.
The drug release profiles were compared using two model-independent methods, mean dissolution time MDTand similarity factor f 2 It is a white powder with a characteristic amine-like odour.
Tablet hardness was found to be good between 12 and 18 kp depending on the compression force applied, and friability was less than 1.
FT-IR spectrum of pure polymers. Increasing the total amount of polymers in the formulation from mg F10 to mg F9 and mg F8 resulted in a slower release rate and extended drug release from the tablet. Evonik Pharma polymers National Center for Biotechnology InformationU.
It can be seen from Fig. The aims of this study were as follows:. To study the effect of anionic and cationic polymer ratio and polymer concentration on the release profile of the drug from the matrix fpo. The increase in polymer concentration resulted in an increase of the MDT values, where for mg polymer concentration the MDT value was 4. J Biomed Mater Res. Indian J Pharm Sci.
There was a problem providing the content you requested
To confirm the diffusion mechanism, the data was further fitted into Korsmeyer-Peppas equation J Adv Pharm Technol Res. Where n is the number of pull points, R t is the reference profile at time point tand T t is the test profile at the same time point; the value of f 2 should be between eudragitt and FT-IR spectrum of treated polymers.
To see MatWeb’s complete data sheet for this material including material property data, metal compositions, material suppliers, etcplease click the button below. Epk thickness of the tablets varied depending on bulk density of the dried granules used and the compression force applied.
HPMCP is cellulose in which some of the hydroxyl groups are replaced with methyl ethers, 2-hydroxypropyl ethers, or phthalyl esters. Several different types of hypromellose phthalate HP50, HP55, HP55S are commercially available with molecular weights in the range 20,—, Our proposal is dependent on the fact that eudragt acidic groups in the enteric polymers may allow for polymer ionization and interaction with the cationic EE even at low pH values.
The rate of eudragih was found eudragiy be different for different polymer combinations, and this could be attributed to the different drug release profiles and mechanisms observed during the dissolution analysis of matrix tablets. The tablets were placed into mL of dissolution medium. Physical Evaluation of the Matrix Tablets Formulated tablets were subjected to the following physical characterization studies.
Evonik EUDRAGIT® E PO Copolymer
The performance of the in situ formed PEC as a matrix for controlled release of drugs was evaluated, using acetaminophen as a model drug. Drug and lactose monohydrate were passed through eusragit sieve and mixed together for 10 min in a polybag.
A physico-chemical approach of polyanion-polycation interactions aimed at better understanding the in vivo behaviour of polyelectrolyte-based drug delivery and gene transfection. Abstract The objective of this study was to compare a novel controlled release tablet formulation based on interpolyelectrolyte complex PEC.
Release Profile Comparison The drug release profiles were compared using two model-independent methods, mean dissolution time MDTand similarity factor f 2 Abhijit Deshmukh for supporting the project. The use of polyelectrolytes in the design of controlled release drug formulations has received notable attention in the recent years because of the capability of the interpolyelectrolyte complex PEC to achieve more sustained drug release than single polymers 1.